Papers

Yingheng Liu, Dajun Wang, Rebecca A. Redetzke, Benjamin A. Sherer, and A. Martin Gerdes Abstract:  Liu Y, Wang D, Redetzke RA, Sherer BA, Gerdes AM. Thyroid hormone analog 3,5-diiodothyropropionic acid promotes healthy vasculature in the adult myocardium independent of thyroid effects on cardiac function. Am J Physiol Heart Circ Physiol 296: H1551–H1557, 2009. First published […]

Stephan Roth, Anita Kinne, Ulrich Schweizer Abstract:  Transport of thyroid hormones across the plasma membrane is required for binding to their nuclear receptors. Monocarboxylate transporter 8 (MCT8) is a plasma membrane thyroid hormone transport protein, which has recently gained much attention, since mutations in MCT8 are associated with severe mental retardation in patients afflicted with […]

Kristin A. Connors, Joe J. Korte, Grant W. Anderson, Sigmund J. Degitz Abstract:  Thyroid hormone (TH) induces the dramatic morphological and physiological changes that together comprise amphibian metamorphosis. TH-responsive tissues vary widely with developmental timing of TH-induced changes. How larval tadpole tissues are able to employ distinct metamorphic programs in a developmental stage- and TH-dependent […]

Caterina Di Cosmo, Xiao-Hui Liao, Alexandra M. Dumitrescu, Nancy J. Philp, Roy E. Weiss, and Samuel Refetoff Abstract:  The mechanism of thyroid hormone (TH) secretion from the thyroid gland into blood is unknown. Humans and mice deficient in monocarboxylate transporter 8 (MCT8) have low serum thyroxine (T4) levels that cannot be fully explained by increased […]

Sigrun Horn, Heike Heuer Abstract:  Thyroid hormone is essential for proper brain development since it acts on processes such as neuronal migration and differentiation, myelination and synaptogenesis. In this review, we summarize the consequences of thyroid hormone deficiency for brain development with special focus on the cerebellum, an important target of thyroid action. In addition, […]

Anita Kinne, Gunnar Kleinau, Carolin S. Hoefig, Annette Grüters, Josef Köhrle, Gerd Krause, Ulrich Schweizer Abstract:  Monocarboxylate transporter 8 (MCT8, SLC16A2) is a thyroid hormone (TH) transmembrane transport protein mutated in Allan-Herndon-Dudley syndrome, a severe Xlinked psychomotor retardation. The neurological and endocrine phenotypes of patients deficient in MCT8 function underscore the physiological significance of carriermediated […]

Takahiko Kogai, Yan-Yun Liu, Laura L. Richter, Kaizeen Mody, Hiroyuki Kagechika, and Gregory A. Brent Abstract:  Retinoic acid (RA) and thyroid hormone are critical for differentiation and organogenesis in the embryo. Mct8 (monocarboxylate transporter 8), expressed predominantly in the brain and placenta, mediates thyroid hormone uptake from the circulation and is required for normal neural […]

Carmen Grijota-Martínez, Diego Díez, Gabriella Morreale de Escobar, Juan Bernal, and Beatriz Morte Abstract:  Mutations of the monocarboxylate transporter 8 gene (MCT8, SLC16A2) cause the Allan-Herndon- Dudley syndrome, an X-linked syndrome of severe intellectual deficit and neurological impairment. Mct8 transports thyroid hormones (T4 and T3), and the Allan-Herndon-Dudley syndrome is likely caused by lack of […]

Simone Kersseboom, Theo J. Visser Abstract:  Thyroid hormone (TH) is important for the development of different tissues, in particular the brain, as well as for the regulation of the metabolic activities of the tissues and thermogenesis throughout life. Most TH actions are initiated by binding of the active hormone 3,3’,5-triiodothyronine (T3) to its nuclear receptor. […]

Gad David Vatine, David Zada, Tali Lerer-Goldshtein, Adi Tovin, Guy Malkinson, Karina Yaniv and Lior Appelbaum Abstract:  Allan Herndon Dudley syndrome (AHDS) is a severe psychomotor retardation characterized by neurological impairment and abnormal thyroid hormone (TH) levels. Mutations in the TH transporter, monocarboxylate transporter 8 (MCT8), are associated with AHDS. MCT8-knockout mice exhibit impaired TH […]